慢性心功能不全时心脏一氧化氮生成增加

Increased cardiac NO production in patients with chronic heart failure

目的 :评价慢性心功能不全 (CHF)患者心脏一氧化氮 (NO)的产生情况 .方法 :2 8例CHF患者和 9例心功能正常对照者同时抽取冠状静脉窦和升主动脉血 .测量血浆NO代谢终产物亚硝酸盐离子 (NO2 -)及硝酸盐离子 (NO3 -)总的含量 (NOx-) .用冠状静脉窦及升主动脉血中NOx-之差来表示心脏所产生的NO量 .结果 :2 8例CHF患者心脏产生的NO量 [(10 .4± 2 .3) μmol·L-1]明显高于正常对照组 [(3.9±1.5 ) μmol·L-1,P <0 .0 1].心脏产生的NO与左室造影法计算的左室射血分数值呈负相关 (r =- 0 .91,P <0 .0 1) .结论 :(CHF)患者心脏产生的NO增加 。

AIM: To assess the cardiac levels of nitric oxide (NO) in patients with chronic heart failure (CHF). METHODS: In 28 cases with CHF and 9 control subjects, blood samples were simultaneously taken from coronary sinus and aorta. Plasma NO end products (nitrate plus nitrite, NO x -) in the samples measured. The amount of NO secreted by the heart was determined by calculating the difference between aorta and the coronary sinus in the plasma NO x - concentration. RESULTS: The cardiac NO levels determined in the 28 patients with mild to severe CHF were significantly higher than those in the control subjects (10.40± 2.30 vs 3.91±1.47 μmol·L -1 , P <0.01). There was a significant negative correlation between NO levels and the left ventricular ejection fraction ( r =-0.91, P <0.01). CONCLUSION: Cardiac NO increases in CHF patients, which is well correlated with functional severity of heart failure.