血清间接胆红素代谢与脑梗死的相关性研究

STUDY ON THE CORRELATION BETWEEN SERUM INDIRECT BILIRUBIN METABOLISM AND CEREBRAL INFARCTION

目的 观察脑动脉硬化性脑梗死患者血清胆红素水平变化 ,探讨低间接胆红素与高血脂所致的脑梗死的相关性。方法 采用酶法对 10 2例急性脑梗死患者及 6 8例正常对照者血清胆红素、血脂进行了测定。结果 脑梗死组总胆红素、间接胆红素显著低于对照组 (P <0 .0 1) ,尤其是脑梗死与间接胆红素水平呈负相关 ,差异显著。结论 血清间接胆红素浓度降低可作为脑梗死的独立危险因素 。

Objective To observe the content changes of serum bilirubin in patients with arteriosclerotic cerebral infarction and to explore the correlation of low indirect bilirubin and hyperlipemia and the cerbral infarction .Methods The contents of bilirubin and blood-lipid in 102 cases of acute cerebral infarction and 68 normal cases were determined by enzyme immunoassay .Results The contents of total bilirubin and indirect bilirubin in the patients with cerebral infarction were found obviously lower than those in the normal cases (P<0.01).Negative correlation was found between cerebral infarction and indirect bilirubin contents .Conclusion Low content of serum bilirubin is an independent risk factor in causing cerebral infarction and is of great value in the study of the formation and biochemical mechanism of arteriosclerotic cerebral infarction .