幽门螺杆菌感染的三联四联疗法比较

COMPARATIVE STUDY ON THE TRIPLE AND TETRAGENOUS THERAPIES FOR INFECTIONS CAUSED BY PYLORIC HELICOBACTERIUM

目的 探讨幽门螺杆菌 (HP)感染的治疗方法。方法 将 183例幽门螺杆菌感染的患者随机分为 3组。A组 :口服胶体次枸橼酸铋 (CBS)、四环素 (TET)、甲硝唑 (MET) ;B组 :口服法莫替丁 (FAM )、TET、MET ;C组 :口服CBS、FAM、TET、MET。结果 控制症状时间 :A组为 (8.5±1.8)d ,B组为 (6 .1± 1.2 )d ,C组为 (3.5± 0 .7)d。三组比较具显著性差异 (F =9.2 1,P <0 .0 1)。清除率 :A组为 81.97% (5 0 6 1) ,B组为 83.6 1% (5 1 6 1) ,C组为 96 .72 % (5 9 6 1)。 3组比较具显著性差异 (χ2 =7.2 6 ,P <0 .0 1)。结论 四联疗法的效果优于三联疗法。

Objective To explore a new therapy to treat infections caused by pyloric helicobacteria.Methods 183 cases of infections caused by pyloric helicobacteria were randomly divided into A.B and C groups.In Group A,the cases received oral administration of colid bismuth citrate(CBS),tetracycline(TET) and metronidazole(MET).In Group B,the cases received oral administration of FAM,TET and MET.In Group C,CBS,FAM,TET and MET were used simultaneously.Results The control time of the symptoms in the three groups were (8.5±1.8) days in Group A,(6.1±1.2) days in Goup B and (3.5±0.7) days(F=9.21,P<0.01).The removing rates were 81.97%(50/61) in Group A,83.61%(51/61) in Group B and 96.72%(59/61) in Group C(χ 2=7.26,P<0.01).Conclusion The tetragenous therapy has proved to be more effective than the triple therapy.