癌胚抗原和环氧化酶2的表达与结直肠癌的关系

Relationship between Carcinoembryonic Antigen and Cyclooxygenase 2 Expression and Colorectal Cancer

背景与目的:已有研究表明,癌胚抗原参与了细胞间的粘附;环氧化酶2可能参与了结直肠癌的发生过程。本研究拟探讨癌胚抗原及环氧化酶2在结直肠癌发生、发展中的意义。方法:应用免疫组化技术(SP法)检测34例结直肠癌组织、癌旁组织、正常粘膜及其中19例转移淋巴结标本中癌胚抗原及环氧化酶2的表达。结果:癌胚抗原在结直肠癌中的表达水平与癌组织细胞分化程度的相关性有统计学意义(P<0.05);而与淋巴结转移、Dukes分期、发病年龄、性别及肿块部位的相关性无统计学意义(P>0.05)。环氧化酶2在大部分癌组织(31/34)和全部转移淋巴结中表达明显升高,但与肿瘤细胞的分化、分期、部位和患者的性别及年龄的相关性无统计学意义(P>0.05)。此外,癌胚抗原和环氧化酶2在癌组织中的表达和在正常肠粘膜中的表达差异均有统计学意义(P<0.01)。结论:癌胚抗原和环氧化酶2的异常表达可能是结直肠癌发生、发展过程中的一个重要环节。

BACKGROUND & OBJECTIVE:Some research showed that carcinoembryonic antigen(CEA) related to cell adhesion and cyclooxygenesis 2(COX2) may be related to colorectal carcinogenesis. This study was designed to investigate the expression of CEA and COX2 to evaluate their effects on the tumorigenesis and progression in the colorectal cancer. METHODS:The immunohistochemistry was used to determine the expression of CEA and COX2 in the 34 tissues of colorectal cancer,border of cancer, normal mucosa,and 19 metastatic lymph nodes. RESULTS:CEA expression level had a correlation with the differentiation of the tumor tissue (P< 0 05), but had no correlation with lymph node metastasis,Dukes stage,the patients age,sex,and the location of tumor (P >0 05). The level of COX2 increased in the majority of tumor tissues (31/34) and all of the lymph node metastases, but had no correlation with the tumor differentiation, stage,location,patients age and sex(P >0 05). There was significant difference of expression of CEA and COX2 between tumor and nontumor tissues (P< 0 01). CONCLUSION:The abnormal expression of CEA and COX2 plays a role in the carcinogenesis and development of colorectal cancer.