肿瘤坏死因子基因多态性与血液系统恶性肿瘤

Review of Relationship between Tumor Necrosis Factor Genetic Polymorphism and Hematological Malignancies

研究表明,包括血液系统恶性肿瘤在内的恶性肿瘤病人血清中肿瘤坏死因子(TNF)升高,过多的TNF产生与TNF基因多态性有关,此种多态性能通过影响TNF的转录调节来影响TNF的表达。本文旨在就TNF基因多态性与淋巴瘤、慢性淋巴细胞白血病、毛细胞性白血病、急性淋巴细胞白血病及多发性骨髓瘤等血液系统恶性肿瘤的相关性作一综述。

Patients with malignant tumor including hematological malignances have high plasma levels of tumor necrosis factor (TNF) and excessive production of TNF is associated with polymorphic variation of TNF locus. TNF polymorphism affects TNF expression by affecting transcriptional regulation. The aim of this paper was to review the correlation between TNF polymorphism and hematological malignancies such as lymphoma, chronic lymphocytic leukemia, hairy cell leukemia, acute lymphocytic leukemia and multiple myeloma and to make preparation for further research of their relationship.