血管瘤组织中雌激素、雌激素受体表达及临床意义

The expression of EST and ER in hemangioma with its clinical value

目的 探讨雌激素 (estrogen ,EST)与血管瘤发生发展的关系。方法 采用免疫组化SP法检测了 38例血管瘤标本及 6例正常对照皮肤组织中EST、雌激素受体 (estrogenreceptor,ER)的表达。结果 毛细血管瘤EST表达增高 ,与海绵状和蔓状动脉瘤及正常皮肤组织间差异显著 ,尽管EST在海绵状和蔓状动脉瘤中表达高于正常对照组 ,但它们之间的差异无显著性意义 ;ER仅在部分毛细血管瘤组织中表达。EST和ER的表达均无性别间差异。结论 EST与毛细血管瘤的发展有密切关系 ,并为我们用药物治疗毛细血管瘤提供了理论依据。

ObjectiveTo study the relationship between estrogen and the development of hemangioma. Methods The expression of EST and ER in samples from the thirty-eight cases of hemangioma and six cases of normal control group was examined with the immunohistochemical steptavidin peroxidase conjugated method ( SP method ). Results The EST in capillary hemangioma expressed significantly higher than in the cavernous hemangioma, the racemose hemangioma or the control group. Although the EST in cavernous hemangioma and racemose hemangioma also expressed higher than in the control, there are no statistical differences among them. The ER only expressed in some cases in the capillary hemangioma group. No sexual difference was shown in the expressions of the EST and the ER. ConclusionThis study shows that there may be a relationship existed between the estrogen and the capillary hemangioma. It may indicate that some capillary hemangioma may be possibly treated by the drugs.;