摘要
In order to investigate the effectof ligustrazine (L ig) i.p. on peritoneal permeability in peritoneal dialysis and its side effects,creatinine was given intravenously and continuously to m aintain the high plasm a creatinine level.All the rabbits were divided into three groups:norm al control group(group A) ,group B treated with0 .12 % L ig and group C treated with0 .2 4 % L ig. The peritoneal dialysis of all rabbits lasted2 h.The plasma and dialysate levels of glucose,protein and creatinine were observed immediate,30 min,6 0 min,90 m in,12 0 min after dialysis.Creasti- nine dialysate/ plasm a ratio (D/ P) ,protein D/ P ratio,glucose D/ Do at different time points after dialysis and creatinine mass transfer area coefficient (MTAC) at 12 0 m in were calculated. The structures of peritoneum were observed under optical microscope and electron microscope after continuously intraperitoneal injection of L ig for14 days.The results showed that the90 - min and 12 0 - min creatinine D/ P ratios in the group C were higher than in the group A.The12 0 - m in creati- nine MATC in the group C was higher than in the group A.The rabbits treated with L ig did not show significant structure changes of peritoneum and signs of peritoneal irritation.Itwas suggest- ed that L ig could increase m ass transfer ability of peritoneum without significant side effects.
In order to investigate the effectof ligustrazine (L ig) i.p. on peritoneal permeability in peritoneal dialysis and its side effects,creatinine was given intravenously and continuously to m aintain the high plasm a creatinine level.All the rabbits were divided into three groups:norm al control group(group A) ,group B treated with0 .12 % L ig and group C treated with0 .2 4 % L ig. The peritoneal dialysis of all rabbits lasted2 h.The plasma and dialysate levels of glucose,protein and creatinine were observed immediate,30 min,6 0 min,90 m in,12 0 min after dialysis.Creasti- nine dialysate/ plasm a ratio (D/ P) ,protein D/ P ratio,glucose D/ Do at different time points after dialysis and creatinine mass transfer area coefficient (MTAC) at 12 0 m in were calculated. The structures of peritoneum were observed under optical microscope and electron microscope after continuously intraperitoneal injection of L ig for14 days.The results showed that the90 - min and 12 0 - min creatinine D/ P ratios in the group C were higher than in the group A.The12 0 - m in creati- nine MATC in the group C was higher than in the group A.The rabbits treated with L ig did not show significant structure changes of peritoneum and signs of peritoneal irritation.Itwas suggest- ed that L ig could increase m ass transfer ability of peritoneum without significant side effects.
