血脂康对高脂血症患者血管内皮功能及血中一氧化氮与内皮素水平的影响

Effect of Xuezhikang on Vascular Endothelial Function and Blood Level of Nitric Oxide and Endothelin in Patients with Hyperlipidemia

目的 :观察血脂康对高脂血症患者内皮依赖性血管舒张功能、血清一氧化氮 (NO)及血浆内皮素(ET)水平的影响。方法 :5 0例高脂血症患者作为试验组 ,5 0例血脂正常的成人为对照组。试验组给予血脂康治疗 8周 ,分别测定试验组治疗前后及对照组的血脂情况、基础肱动脉内径、内皮依赖性血流介导的舒张反应 (flowmediateddilationFMD)、非内皮依赖性硝酸甘油介导的舒张反应及血清NO水平、血浆ET水平。结果 :与对照组比较 ,高脂血症患者FMD反应明显受损 ,血清NO水平降低、血浆ET水平升高 (P <0 0 1) ;基础肱动脉内径及非内皮依赖性硝酸甘油介导的舒张反应无明显差异 (P >0 0 5 )。高脂血症患者应用血脂康治疗 8周后 ,血脂异常明显改善 ,FMD明显提高 ,血清NO水平升高 ,血浆ET水平降低 (P <0 0 1)。结论 :血脂康可改善高脂血症患者的血脂异常 ,并明显提高患者的血管内皮功能。

Objective: To study the effects of Xuezhikang (XZK) on vascular endothelial function (VETF), serum nitric oxide (NO), plasma endothelin (ET) in patients with hyperlipidemia. Methods: Fifty patients with hyperlipidemia were allocated in the treated group, and 50 adult subjects with no hyperlipidemia were allocated in the control group. XZK was given to the treated group for 8 weeks. The changes of blood lipids, serum NO, plasma ET, baseline inner diameter of brachial artery (BD BA), endothelium dependent blood flow mediated dilation (FMD), and non endothelium dependent nitroglycerin mediated dilating response (DR) were observed. Results: As compared with the control group, FMD in the patients with hyperlipidemia was injured significantly, accompanied with serum NO lowered and plasma ET increased (P<0 01), but the BD BA and DR showed no significant difference between the two groups. After patients had been treated with XZK for 8 weeks, significant improvement was shown in lipid abnormality, FMD raised obviously, serum NO increased and plasma ET lowered (P<0 01). Conclusion: XZK could improve the abnormal elevated blood lipids and increase the endothelial function significantly in patients with hyperlipidemia.