纳洛酮治疗急性脑梗死的临床疗效观察

Clinical curative effects of naloxone on acute cerebral infarction(ACI)

目的 探讨纳洛酮治疗急性脑梗死的临床疗效。方法 将 12 2例急性脑梗死患者随机分为治疗组(6 2例 )和对照组 (6 0例 ) ,治疗组用 5 % GS 2 5 0 ml+纳洛酮注射液 0 .8mg静滴 ,每日 2次 ,14 d为 1疗程 ;对照组用 5 % GS2 5 0 ml+复方丹参 16 ml静滴 ,每日 1次 ,14 d为 1疗程。两组均在 1个疗程后进行治疗前后疗效比较和起效时间比较。结果 治疗组总有效率为 93.5 % ,对照组为 76 .7% ,两者比较差异有显著性 (P>0 .0 5 )。其治疗组的起效时间明显优于对照组 (P>0 .0 5 )。

Objective To investigate the clinical curative effects of naloxone on ACI.Methods One hundred and twenty two patients were randomly divided into treated group(n=62) and control group(n=60).In treated group the regimen of 5% GS 250 ml+naloxone injetion 0.8 mg infused intravenously two times a day was administered for 14 day and in contol group the 5% GS 250 ml+ danshen co.injection 16 ml infused intravenously once a day was administered for 14 day.After 14 day the curative effect changes were observed and compared in two groups before and affter therapy.The time when the methods came into play was also compared.Results The total effecive rate in the treated group was 93.5% but 76.7% in control group so that the curative effect in treated group as significantly superior to those in control group( P <0.05).The time of having effect in treated group after therapy were significantly superior to those in control group( P <0.05).Conclusion The clinical curative effects of the naloxone in the treatment of ACI are prominent.