吸附溶出伏安法测定普罗帕酮的研究

Determination of Propafenone by Adsorptive Stripping Voltammetry

在pH 6.47的磷酸盐缓冲溶液中,可得到普罗帕酮的吸附溶出峰。峰电位为-1.38V(vs.Ag/AgCl),富集1min,溶出峰电流与普罗帕酮浓度在8.0x10^(-9)～7.0x10^(-7)mol/L范围内呈线性关系。富集4min检测下限为3.0×10(-10)mol/L。该法用于测定普罗帕酮制剂及人血清中的痕量普罗帕酮,均得到了满意的结果,并探讨了电极反应过程机理。

In a medium of phosphatic buffer (pH 6.47), a sensitive adsorptive stripping peak of propafenone was obtained. The peak potential is at-1.38V(vs.Ag/AgCl). The relationship between peak current and the concentration of propafenone is linear in the range of 8.0×10^(-9)～7.0×10^(-7)mol/L. The detection limit of propafenone is down to 3.0×10^(-10)mol/L by 4 min preconcentration. Satisfactory results have been obtained in the determination of trace amounts of propafenone in human serum. The effect of preconcentration potential, preconcentration time, electrochemical behaviour and the mechanism of electrode reactions has been investigated. The number of electron-transfer and reactive H^+ in the reaction have also been determined.