大黄(庶虫)虫丸对非胰岛素依赖型Ⅳ期糖尿病肾病患者Ⅷ因子相关抗原及纤维蛋白原的影响

Effects of Da Huang Zhe Chong Pill on VI factor correlative antigen and fibrinogen in the patient of non-insulin dependent diabetic nephropathy at stage IV

目的:探讨大黄(庶虫)虫丸对非胰岛素依赖型Ⅳ期糖尿病肾病(DN)患者Ⅷ因子相关抗原(vWF:Ag)、纤维蛋白原(Fbg)的治疗作用。方法:选择Ⅳ期DN患者60例,用自动凝血机检测vWF:Ag、Fbg的变化,并随机分为治疗组和对照组。治疗组用大黄(庶虫)虫丸,对照组用潘生丁干预治疗,观察大黄(庶虫)虫丸对Ⅳ期DN患者vWF:Ag、Fbg的影响。结果:Ⅳ期DN患者血vWF:Ag、Fbg含量显著增高,与正常对照组比较有极显著差异(P<0.01)。用大黄(庶虫)虫丸治疗后,vWF:Ag、Fbg浓度显著降低(P<0.05或P<0.01),明显优于潘生丁组。结论:大黄(庶虫)虫丸能显著降低Ⅳ期DN患者血vWF:Ag、Fbg含量,改善高凝状态。

Objective: To probe into the action of Da Huang Zhe Chong Pill on VI factor correlative antigen (vWF: Ag) and fibrinogen (Fbg) in the patient of non-insulin dependent diabetic nephropathy (DN) at stage Ⅳ. Methods: 60 cases of DN at stage IV were randomly divided into treatment group and control group, and vWF: Ag and Fbg changes were detected with autonomic coagulation instrument. The treatment group were treated with Da Huang Zhe Chong Pill and the control group with persantine. The effects of Da Huang Zhi Chong Pill on vWF: Ag and Fbg in the patient of DN at stage IV were investigated. Results: The blood vWF: Ag, Fbg contents in the patient of DN at, stage Ⅳ increased as compared with that of the normal control group (P <0. 01); after treatment with Da Huang Zhe Chong Pill, vWF: Ag and Fbg contents decreased significantly (P<0. 05 or P<0. 01), superior to that of the persantine. Conclusion: Da Huang Zhe Chong Pill can significantly decrease blood vWF: Ag and Fbg contents and improve hypercoagulative state in the patient of DN at stage Ⅳ .