干扰素治疗慢性乙肝反应的研究

Observation on Regularity and Characteristics of Response to Interferon Treatment for Chronic Hepatitis B

目的 总结干扰素治疗慢乙肝的反应规律及特点。方法 15 0例慢乙肝患者随机分为干扰素治疗组和一般护肝的对照组。采用前瞻性研究方法 ,对治疗组患者定期连续进行肝功能试验、HBVDNA斑点杂交检测、HBVDNA定量PCR检测、乙肝病毒标记物检测。结果 干扰素治疗过程中 ,转氨酶总体呈下降趋势 ;HBeAg应答与患者治疗前转氨酶有关 ,转氨酶重中度升高患者下降明显 ;用药前HBVDNA阳性患者、开始用药后第 2月末HBVDNA转阴者 ,HBeAg转阴率较高。HBeAg应答大多发生在治疗第 3月左右 ,平均转阴时间为 3 .4月 ;干扰素治疗前HBVDNA女性低于男性 ,HBeAg应答组低于无应答组。治疗过程中HBVDNA在总体上呈下降趋势 ,转阴平均时间为 1.9月 ,与HBeAg应答及肝功能恢复有一定相关性。

Objective To summarize the regularity and and characteristics of response to interferon treatment for patients with chronic hepatitis B(CHB).Methods 150 cases of CHB were randomly divided into two groups:interferon therapy (observation group,n=90)and routine protecting liver(control group,n=60)By prospective researching programme,HBV markers,including liver function test were continous periodically detected simultaneously,HBV-DNA quantitative blot hybridization,HBV-DNA quantitative PCR determination were performed.Results The typical responsiveness curve of transaminase decreased rapidly,was accompanied with the use of interferon. HBV DNA turns negative earlier than HBeAg doses. In those patients who was response to interferon completely after interferon administration,the HBV DNA and HBeAg turning negative average time was 1 9 and 3 4 months respectively. The level of HBV DNA was continuons decreased in all patients treated with interferon. HBV DNA quantitative PCR provide more accuracy of viral copies in patient's peripheral blood than that in dot hybridization in interferon therapy.conclusions Interferon the treatment for patients with CHB is effectiveness.