原发性肝癌患者及其家族成员血清免疫抑制酸性蛋白的分析

Analysis of Serum Immunosuppressive Acidic Protein in Patients With Primary Hepatocellular Carcinoma and Their Familial Members

目的 评估血清免疫抑制酸性蛋白 (IAP)与原发性肝癌 (PHC)发生的相关性。方法 应用单向免疫琼脂扩散法检测3 0例PHC患者、3 0例家族成员 (FM)和 3 0例正常健康人 (NS)血清IAP水平。结果 PHC患者血清IAP水平 (85 1± 2 12 ) μg/ml与正常健康人 (2 78± 10 4) μg/ml比较有显著差异 (P <0 0 1) ;FM组 (5 73± 2 2 8) μg/ml与NS组比较有统计学差异 (P <0 0 1)。结论 IAP水平的改变可能与PHC发生相关 ,且IAP检测可被用于PHC易患个体的筛选。

Objective To evaluate the relationship between immunosuppresive acidic protein(IAP) and carcinogenesis of primary hepatocellular carcinoma (PHC).Methods Sera immunosuppresvie acidic protetin level were determined by using single immunodiffusion method in 30 patients with primary hepatocellular carcinoma(PHC),30 their familial members(FM) and 30 normal subjects(NS).Results Serum levels of IAP in patients with PHC(851±212)μg/ml, compared with NS(278±104)μg/ml, were significantly increased (P<0 01). There was also statistical difference in serum levels of IAP between FM(573±228)μg/ml and NS (P<0 01).Conclusions It is suggested that IAP may be associated with carcinogenesis of PHC. The changes of IAP may be served as an indicator of diagnosis for susceptible individuals of PHC.