系统性红斑狼疮累积器官损害及其影响因素研究

Study of Cumulative Organ Damage of Systemic Lupus Erythematosus (SLE) and It's Affecting Factors

目的 探讨系统性红斑狼疮 (SLE)累积器官损害的规律及其影响因素。方法 对 162份SLE病历资料进行回顾性分析 ,采用SICC/ACR损害指数评估其累积器官损害并分析评价其影响因素。结果 累积器官损害同首诊时间、合用环磷酰胺冲击治疗、复发次数及补体水平呈显著性相关 ;而与性别、年龄、病程及皮质类固醇激素累积剂量无显著性相关。结论 累积器官损害是评价SLE病情的指标之一 ,其发生、发展受多因素相互作用。应早期治疗并连续观察实验室指标尤其是血清补体水平 。

Objective To investigate the cumulative organ damage of systemic lupus erythematosus (SLE) and It's affecting factors.Methods 162 cases of SLE patients were reviewed and evaluated in the cumulative organ damage of them . At the same time, It's affecting factors were analysed by multifactorial analysis.Results The cumulative organ damage of SLE was obviously correlated with the first time of treatment, treatment with CTX ,the numbers of recurrence rate and level of complements;but were not correlated with disease duration and cumulative dosage of corticosteroid.Conclusions The cumulative organ damage was one of the evaluating factors of SLE disease, and it's occurence and development were affected by multiple factors .So, the patients should be treated with hormone and control the beneficial factors to protect organs,such as,observation on complemets level,high dosage cyclophosphamide pulse treatment etc.