疱疹病毒性脑炎的病原分析

Pathogeny Analysis of Herpes Viral Encephalitis

目的 探讨病毒性脑炎与疱疹病毒感染的关系 ,了解疱疹病毒性脑炎的主要致病原。方法 应用聚合酶链反应(PCR)检测病毒性脑炎患者脑脊液中HSVⅠ -DNA ,HSVⅡ -DNA ,VZV -DNA ,HCMV -DNA ,EBV -DNA。结果 5 2 6例病毒性脑炎患者中有 82例 (15 6% )诊断为单纯疱疹病毒性脑炎 ,0～ 10岁为高发年龄组。 9例 (1 7% )为巨细胞病毒性脑炎 ,7例 (1 3 % )为水痘 -带状疱疹病毒性脑炎 ,4例 (0 7% )为EB病毒性脑炎。结论 疱疹病毒性脑炎以单纯疱疹病毒为主要致病原 。

Objective To probe into the relationship between the viral encephalitis and herpes viral infection, to understand the primary patheogeny of herpes viral encephalitis.Methods HSVⅠ-DNA,HSVⅡ-DNA,VZV-DNA,HCMV-DNA,EBV-DNA in CSF from viral encephalitis patients were detected by PCR.Results 82(15 6%) cases of 526 patiens with viral encephalitis were diagnosed as herpes simplex viral encephalitis, of which the age of high morbidity was at 0～10 years old children,9(1 7%) cases as cytomegaloviral encephalitis,7(1 7%) cases as varicella-zoster viral encephalitis and 4(0 7%) cases as EB viral encephalitis.Conclusions Herpes simplex viruses are the primary pathogeny in herpes viral encephalitis, PCR technique is valuable for the diagnosis of herpes viral encephalitis.