威草胶囊治疗尿酸性肾病的实验研究

EXPERIMENTAL STUDY ON CAPSULE WEICAO ON URIC ACID NEPHROPATHY IN RAT

目的 :探讨威草胶囊对尿酸性肾病大鼠模型的治疗效果及其可能作用机理。方法 :用腺嘌呤加沙丁鱼造模 ,并将大鼠分为正常对照组、模型空白组、小剂量威草胶囊治疗组、大剂量威草胶囊治疗组、别嘌呤醇治疗组 ,在造模的同时 ,分别给予以上述药物灌胃 ,在实验前及实验后测定大鼠的血尿酸 (UA)、尿素氮 (BUN)、血肌酐 (Scr)、黄嘌呤氧化酶 (XOD)、尿尿酸、内生肌酐清除率 (Ccr)、2 4h蛋白尿、肾指数及肾脏病理组织检查。结果 :4周后威草胶囊明显改善模型大鼠的一般症状 ,与模型组大鼠相比 ,治疗组大鼠的血尿酸明显减少 ,尿尿酸明显增多 ,肾功能改善 ,黄嘌呤氧化酶活性下降 ,肾指数下降 ,纤维化程度减轻 ,肾组织内尿酸盐沉积物减少 (P <0 .0 1)。结论 :威草胶囊对尿酸性肾病大鼠有明显的治疗效果。

Objective:To study the effect of Capsule Weicao on uric acid nephropathy in rat. Methods:Uric acid nophropathy rat was made by using Adenine and sardines. Fifty male Sprague-Dawley rats are divided into control group, uric acid nophropathy control group, Capulse Weicao small dose treated group,Capulse Weicao big dose treated group and allopurinol treated group. At the end of experimental, the UA, BUN, Scr, XOD, Ccr and mine protein in 24 hours were detected ,the pathology of the kidney was examined.Results:The results indicated that Capulse Weicao can improve the signs in rat with uric acid nephropathy. Compared with the uric acid nephropathy control group, the UA, BUN ,Scr, XOD and mine protein in 24 hours were decreased obviously ( P < 0.01),crystals in renal tissue decreased and the proliferation of fibroid tissue was aueviated. Conclusions:Capulse Weicao has a markedly therapeuric effect on uric acid nephropathy in rat.