大黄对全身炎症反应综合征患者肾功能的影响

Effect of rhubarb on the renal function of patients with systemic inflammatory response syndrome

目的 :探讨大黄对全身炎症反应综合征 (SIRS)患者肾功能的影响。方法 :将 6 2例无肾功能不全的SIRS患者随机分成两组 ,对照组 (30例 )给予常规对症支持治疗 ,中西医结合治疗组 (32例 )加用生大黄泡水鼻饲 5 d。分别检测所有患者治疗前、治疗 2 4 h后、治疗 12 0 h后的血浆内皮素、血肌酐、尿微量白蛋白和 β2 微球蛋白。结果 :治疗 12 0 h后 ,治疗组上述 4项指标均较对照组明显降低 (P<0 .0 5或 P<0 .0 1)。结论 :大黄对SIRS患者的肾功能有保护作用。

Objective:To investigate the effect of rhubarb on the renal function of patients with systemic inflammatory response syndrome (SIRS).Methods:Sixtytwo patients of SIRS with normal renal function were randomly divided into two groups.Thirty patients were treated with conventional therapy(control group ), 32 patients were treated with both rhubarb through nose feeding for 5 days and conventional therapy(therapy group). Plasma endothelin (ET),plasma creatinine(SCr),urine trace albumin(ALB),urine β 2 microglobin (β 2MG) were measured in all patients respectively before therapy,24 hours after therapy,120 hours after therapy.Results:One hundred and twenty hours after therapy,all the four parameters(ET,SCr,ALB, βMG ) in the therapy group were decreased significantly than those in the control group( P <0 05 or P <0 01). Conclusion: Rhubarb can protect the renal function of patients with SIRS.