脑出血血肿冲洗液炎性细胞因子动态变化的研究

Dynamic change of inflammatory cytokine in hematomal fluid of cerebral hemorrhage

目的 动态观察脑出血血肿冲洗液炎性细胞因子的变化及意义。方法 以 1999年 1月～ 2 0 0 2年 1月我科行微创颅内血肿清除术的 80例中的重度 (出血量 >30mL)高血压脑出血患者为研究对象 ,连续监测血肿冲洗液中肿瘤坏死因子(TNF -α)、白细胞介素 - 6 (IL - 6 )、白细胞介素 1- β(IL - 1β)的动态变化。 结果 高血压脑出血发病 6h血肿冲洗液中即已检测出TNF -α、IL - 6、IL - 1β ,在出血急性期呈现不同变化趋势。 结论 高血压脑出血后炎性细胞因子参与了其后的病理过程 ,其水平的变化与疾病的转归有关。

Objective To investigate the dynamic change of inflammatory cytokine in hematomal fluid after hypertensive cerebral hemorrhage and to explore the clinical significance. Methods From 1991.1 to 2002.1, 80 patients accepted micro-injury operation in ICU were studied,and the changes of TNF-α, IL-6, IL-1β in hematomal fluid were observed continuously. Results TNF-α, IL-6, IL-1β were observed in hematomal fluid at 6 h after hypertensive cerebral hemorrhage and reached peaks at different times. Conclusions Inflammatory cytokine was involved in the pathological process of cerebral hemorrhage and was relevant to the prognosis of hypertensive cerebral hemorrhage.