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ABC转运蛋白与肿瘤多药耐药 被引量：1

ABC transporters and multidrug resistence in cancer
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摘要 目的 :介绍ABC转运蛋白与肿瘤多药耐药的研究进展 ,阐述ABC转运蛋白高表达是多药耐药的重要机制之一。方法 :检索国内外大量文献资料进行汇总、综述。结果 :ABC转运蛋白是具有ATP结合区的单向底物外排泵。P -糖蛋白高表达是肿瘤细胞产生多药耐药的经典路径 ,多药耐药相关蛋白高表达能导致非P -糖蛋白介导的多药耐药。结论 :开发多药耐药蛋白抑制剂有广阔的应用价值 。
作者 王彦 刁亚英 姜远英
机构地区 第二军医大学药学院 第二军医大学附属长海医院药学部
出处 《药学实践杂志》 CAS 2003年第1期28-31,共4页 Journal of Pharmaceutical Practice
关键词 ABC转运蛋白 多药耐药 肿瘤
分类号 R730.53 [医药卫生—肿瘤] R979.1 [医药卫生—药品]
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二级参考文献10

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共引文献3

同被引文献39

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药学实践杂志
2003年 第1期

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