ABC转运蛋白与肿瘤多药耐药
被引量:1
ABC transporters and multidrug resistence in cancer
摘要
目的 :介绍ABC转运蛋白与肿瘤多药耐药的研究进展 ,阐述ABC转运蛋白高表达是多药耐药的重要机制之一。方法 :检索国内外大量文献资料进行汇总、综述。结果 :ABC转运蛋白是具有ATP结合区的单向底物外排泵。P -糖蛋白高表达是肿瘤细胞产生多药耐药的经典路径 ,多药耐药相关蛋白高表达能导致非P -糖蛋白介导的多药耐药。结论 :开发多药耐药蛋白抑制剂有广阔的应用价值 。
出处
《药学实践杂志》
CAS
2003年第1期28-31,共4页
Journal of Pharmaceutical Practice
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