围手术期胶质瘤患者细胞免疫功能的表达

Changes of perioperation cellular immune function in patients with gliomas

目的 探讨围手术期胶质瘤患者细胞免疫功能的表达。方法 用免疫荧光技术检测 4 8例胶质瘤患者围手术期T淋巴细胞亚群和NK细胞百分率。结果 胶质瘤患者CD3、CD4 、CD8及CD4 /CD8比值均明显低于对照组 ;肿瘤切除术后细胞免疫功能有所恢复 ,但与术前比较无明显差异 ,且仍低于正常状态。结论 胶质瘤患者细胞免疫功能低下 ,且肿瘤切除术后其细胞免疫功能尚难很快恢复到正常状态 ,临床上应注意围手术期细胞免疫功能的保护。

Objective The cellular immune function was investigated before and after operation in patients with glioma.Methods The positive percentage of T lymphocyte phenotype and NK cell were examined dynamically by method of direct immunofluorence. Results The percentage of CD 3 ?CD 4 ?CD 8 and the ratio of CD 4 /CD 8 in glioma patients were much lower than those of the controls. The cellular immune function increased slightly after tumor removal. But there was no significant difference between the before and after operation, and the cellular immune function was significantly lower in postoperation than those in normal status. Conclusion The cellular immune function in glioma patients was depressed, and it is difficult for the cellular immune function to recover in short time after tumor removal.