婴儿肺炎肺炎衣原体感染的血清免疫荧光法诊断及临床分析

Chlamydia pneumoniae infection in infants with pneumonia

目的 探讨肺炎衣原体 (Cpn)在婴儿肺炎中的感染情况。 方法 对符合肺炎诊断标准的 1岁以内患儿 2 6 9例 ,使用荧光免疫方法检测Cpn抗体 ,并进行统计学分析。 结果 2 6 9例肺炎患儿中 ,急性Cpn感染的感染率为 15 2 % ,既往感染的感染率为 2 4 5 % ,。 1999年检测 134例中 ,Cpn急性感染为 4 5 % ,既往感染为2 5 4% ;2 0 0 0年检测 135例中 ,Cpn急性感染为 2 5 9% ,既往感染为 2 3 7%。两年度比较 ,Cpn既往感染率接近(P >0 0 5 ) ,而Cpn急性感染率差异有非常显著意义 (P <0 0 1) ,2 0 0 0年急性感染率比 1999年明显增高。结论 Cpn是婴儿肺炎的重要病原之一 ,且具有流行性。

Objective To explore the status of chlamydia pneumoniae (Cpn) infection in infant pneumonia.Methods A prospective study for Cpn infection was conducted in 269 infants with pneumonia,serum immunoglobulin G and M (IgG and IgM) classes of antibodies to Cpn were studied by MIF test and were analyzed.Results Of the 269 infants with pneumonia, evidence of acute chlamydia pneumoniae infection was found in 41 case (152%), of which 6 cases (44%) were seen in 1999 and 35 cases (259%) in 2000,respectively. The number of acute chlamydia penumoniae cases seen in 2000 was obviously higher than in 1999 (P<01). Conclusion Cpn infection is an important cause of pneumonia in infants and it is of prevalence.