期刊文献+

支气管哮喘合并变应性鼻炎患者发病时序性及病情的关联性研究 被引量:4

Studies on the correlation between occurrence tune series and its severity in patients of bronchial asthma complicated with allergic rhinitis
原文传递
导出
摘要 目的 探讨支气管哮喘合并变应性鼻炎患者发病的时序性和病情的关联性。方法 回顾性分析了1996~2002年我院哮喘门诊的583例哮喘患者的病历资料,将其分为2组,Ⅰ组为单纯哮喘组,Ⅱ组为哮喘合并变应性鼻炎组。结果 单纯哮喘组共292例(50.1%),哮喘合并变应性鼻炎组共291例(49.9%)。2组患者中,Ⅱ组患者伴发疾病(如鼻息肉、鼻窦炎、特应性皮炎)和过敏史(包括食物过敏、药物过敏及皮肤变应原皮试阳性)均明显高于Ⅰ组(P<0.01)。其中哮喘-鼻息肉-阿司匹林过敏三联症的发病率(19例,6.5%)亦明显高于Ⅰ组(3例,1.0%)。Ⅱ组患者其鼻炎发病以常年性鼻炎为多,占62.2%,季节性鼻炎中以秋季多发(16.8%);其中55.7%的患者接受了鼻炎的治疗,且以单用或联合使用抗组胺药物和鼻内糖皮质激素为主要治疗措施。哮喘合并变应性鼻炎的患者中53.3%(155/291)先发生变应性鼻炎,平均72.4个月(6.0年)后发生哮喘,有33.7%(98/291)的患者先发生哮喘,平均96.9个月(8.1年)后发生变应性鼻炎。鼻炎发作加重哮喘者占61.9%(180/291),控制鼻炎哮喘症状减轻者占51.2%(149/291)。结论 变应性鼻炎与支气管哮喘在发病的时序性和病情关联性方面存在一定相关性,提示这两种疾病可能是同一种疾病在不同部位的表现,两者联合防治具有实际的意义。 Objective To investigate the correlation between occurrence time and condition severity in patients of bronchial asthma complicated with allergic rhinitis. Methods The 583 outpatients with asthma in an asthma clinic during 1996-2002 were divided into simple asthma group (Group Ⅰ with 292 cases) and asthma complicated with allergic rhinitis group (Group Ⅱ with 291 cases), and their data were compared and statistically analyzed. Results The proportion of those complicated with other diseases, e.g. , nasal polyp, sinusitis, atopic dermatitis, and with a history of allergy, e.g. , food allergy, drug allergy and positive skin allergic test, was significantly higher in the Group Ⅱ than that in the Group Ⅰ ( P < 0.01). Incidence of triad (asthma-nasal polyp and aspirin-allergy) was 6.5% (19/291) in the Group Ⅱ, significantly higher than that in the Group Ⅰ (1.0% , 3/292). Regular rhinitis was common in the Group Ⅱ (62.2%) and 16.8% of seasonal rhinitis occurred in the fall (16.8%), and 55.7% of the patients received treatment for rhinitis with antihistamine drugs alone or combined use of antihistamine drugs and glucocorticoids. Allergic rhinitis occurred first and asthma occurred six years (72.4 months) later in average in 53.3% (155/291) of the patients of asthma complicated with allergic rhinitis. And, asthma occurred first and then allergic rhinitis occurred 8.1 years (96.9 months) in average later in them. Attack of rhinitis in 61.9% of the patients (180/291) aggravated their asthma, and control of rhinitis in 51.2% (149/291) of them alleviated their asthma symptoms. Conclusions There existed relationship, to certain extent, between the occurrence time series and the severity of the condition in patients of asthma complicated with allergic rhinitis, which suggested that allergic rhinitis and bronchial asthma could be the same kind of disease but manifest in different sites. Combined prevention and treatment for both asthma and allergic rhinitis are feasible.
作者 苏楠 林江涛
出处 《中华全科医师杂志》 2003年第1期18-20,共3页 Chinese Journal of General Practitioners
关键词 支气管哮喘 变应性鼻炎 发病时序性 病情 关联性研究 Asthma Rhinitis allergic, perennial Correlation
  • 引文网络
  • 相关文献

参考文献1

二级参考文献5

  • 1计焱焱,郑静华,姚光弼.变应性鼻炎和哮喘的变应原皮试和脱敏治疗[J].上海免疫学杂志,1995,15(4):244-245. 被引量:2
  • 2吉晓摈,中国中西医结合耳鼻咽喉科杂志,1997年,5卷,2期,83页
  • 3李明华,支气管哮喘的现代治疗,1995年,350页
  • 4顾瑞金,中华耳鼻咽喉科杂志,1991年,26卷,3期,134页
  • 5顾瑞金,临床变态反应疾病,1991年,200页

共引文献1

同被引文献44

引证文献4

二级引证文献17

;
使用帮助 返回顶部