肥胖患者胰升糖素水平变化及其对空腹血糖的影响

Changs of glucagon in patients with obesity and it's effects on fasting plasma glucose

目的 探讨肥胖患者胰升糖素的变化特点及其对血糖的影响。方法 将 82例患者根据体重指数分为 3组 :A组 (BMI <2 4,n =2 3 )、B组 (2 4≤BMI <2 7,n =2 7)、C组 (BMI≥ 2 7,n =3 2 ) ,分别测定胰升糖素、胰岛素、空腹血糖 ,采用单因素方差分析法与Spearman等级相关性分析法进行分析。结果 3组胰升糖素分别为 (15 6.3± 5 8.6)、(186.7± 67.5 )、(2 2 2 .2± 88.4)ng·L-1,C组与A组比较有显著性差异 (P <0 .0 1) ;3组胰岛素分别为 (15 .4± 4.7)mIU·L-1、(2 0 .6± 9.6)mIU·L-1、(2 2 .3± 10 .6)mIU·L-1,B组、C组与A组比较差异有显著意义 (P <0 .0 5、P <0 .0 1) ;B、C两组胰升糖素与空腹血糖呈正相关。结论 肥胖患者胰岛素、胰升糖素一致性增高 ,胰升糖素的增高是空腹血糖增高的重要因素。

Objective To explore the effects of glucagon on fasting plasma glucose(FPG) in patients with obesity.Methods 82 cases with obesity were divided into 3 groups according to body mass index(BMI), group A(BMI<24, n =23),group B(24≤BMI<27, n =27) and group C(BMI≥27, n =32).Glucagon and plasma insulin were measured by radioimmunoassay.Results The contents of glucagon in the group C〔(222.2±88.4)ng·L -1 〕 were significantly higher than that of the group A〔(156.3±58.6)ng·L -1 〕( P <0.01).The contents of plasma insulin in the group B〔(20.6±9.6)?mIU·L -1 〕 and group C〔(22.3±10.6)mIU·L -1 〕 were significantly higher than that of group A〔(15.4±4.7)mIU·L -1 〕( P <0.05, P <0.01).Conclusion Glucagon and plasma insulin consistently increased in patients with obesity.The increase of glucagon is a important factor for increase of FPG.