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胰岛素样生长因子1的系统生物学特性及其在冠心病发病中之作用 被引量：1

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摘要 胰岛素样生长因子 1(IGF1)是胰岛素家族中一员 ,近来发现在动物的体内存在着 IGF1系统或 IGF1轴 ,不仅作为内分泌系统中调节动物生长发育的一员 ,还通过自分泌、旁分泌机制参与多种生理及病理生理活动 。
作者 朱志军
机构地区 浙江大学医学院附属第一医院心内科
出处 《心脏杂志》 CAS 2002年第5期433-434,437,共3页 Chinese Heart Journal
关键词 胰岛素样生长因子1 冠状动脉疾病 系统生物学 IGFl
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献14

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同被引文献12

  • 1黄顺伟,高修仁,唐可京.原发性高血压患者循环中IGF-1水平与心肌肥厚的研究[J].中国病理生理杂志,2005,21(4):696-699. 被引量：10
  • 2TADDEI S, VIRDIS A, GHIADONI L, et al. Effects of antihypertensive drugs on endothelial dysfunction: clinical implications [J]. Drugs, 2002, 62(2):265 -284.
  • 3HOLWERDA N J, FOGARI R, ANGELI P, et al. Valsartan, a new angiotensin Ⅱ antagonist for the treatment of essential hypertension:efficacy and safety compared with placebo and enalapril [J] . J Hypertens, 1996, 14(9): 1147-1151.
  • 4REN J, SAMSON W K, SOWERS J R, Insulin-like growth factor Ⅰ as a cardiac hormone: physiological and pathophysiological implications in heart disease [J]. J Mol Cell Cardiol, 1999, 31 (11 ) :2049 -2061.
  • 5VECCHIONE C, COLELLA S, FRATYA L, et al. Impaired insulin-like growth factor Ⅰ vasorelaxant effects in hypertension [J].Hypertension, 2001, 37 (6) : 1480 - 1485.
  • 6VERDECCHIA P, REBOLDI G, SCHILLACI G, et al. Circulating insulin and insulin growth factor-1 are independent determinants of left ventricular mass and geometry in essential hypertension [J] .Circulation, 1999,100(17) : 1802 - 1807.
  • 7NATHAN C. Nitric oxide as a secretory product of mammalian cells[J]. FASEB J, 1992, 6(12):3051-3064.
  • 8ISENOVIC E, MUNIYAPPA R, MILIVOJEVIC N, et al. Role of P13-kinase in isoproterenol and IGF-1 induced ecNOS activity [J] .Biochem Biophys Res Commun, 2001,285 (4) : 954 - 958.
  • 9STANDLEY P R, STANLEY M A, SENECHAL P. Activation of mitogenic and antimitogenic pathways in cyclically stretched arterial smooth muscle [J]. Am J Physiol Endocrinol Metab, 2001, 281 (6) :E1165- 1171.
  • 10NOLAN B P, SENECHAL P, WAQAR S, et al. Altered insulin-like growth factor-1 and nitric oxide sensitivities in hypertension contribute to vascular hyperplasia [J] . Am J Hypertens, 2003, 16(5 Pt 1):393 - 400.

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心脏杂志
2002年 第5期

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