酒精性肝病患者3种细胞因子变化的初步研究

Altered Three Kinds of Cytokine in Alcoholic Liver Disease

目的:探讨两种前炎症细胞因子,一种促细胞生长因子在酒精性肝病中的改变。方法:用放免法检测61例酒精性肝病病人血清中的TGF-α,TNF-α,IL-1β。结果:TGF-α(23.84±17.46)pg/ml(t=9.11,P<0.01),TNF-α(1.59±0.77)ng/ml(t=2.75,P<0.05),IL-1β(0.56±0.56)ng/ml(t=4.93,P<0.01)。显著高于正常对照。胆红素升高者的TNF-α、IL-1β显著高于胆红素正常者(P<0.05)。22例病人治疗后TNF-α、IL-1β比治疗前显著降低(P<0.05),而TGF-α则略升高(21.68±21.52 vs 26.25±21.91,t=1.245,P=0.227)。结论:两种前炎症细胞因子在酒精性肝病的发生中可能起重要作用。细胞生长因子则与炎症、坏死致肝细胞再生似有一定联系。

Objective: To invetigate the changes of two kinds of proinflammation cytokine and one kind of growth-promoting factor in alcoholic liver disease. Methods: The serum TGF-α, TNF-α, IL-1β in sixty-one patients with alcoholic liver disease were measured by radioimmunoassay, and then compared the results of measurnent between the patients and normality. Results: It showed a high significancet difference. There were (23.84 ± 17.46) pg/ml in TGF-α, TNF-α (1.59±0.77) ng/ml and IL-1β(0.56±0.56) ng/ml, TNF-α, IL-1β in patients with elevated bilirubin was higher than the normalization (P<0.05). TNF-α and IL-1β lowered markedly in 22patients after treatment, and TGF-α elevated slightly. Conclusions: Two kinds of proinflammation cytokine might take an main effect during the development of alcoholic liver disease. It seemed that there was a connection among the growth factor, inflammation and mecrosis causing hepatocyte regerertion.