高血压合并腔隙性脑梗死转移生长因子β_1的变化

Transforming Growth Factorβ1 in Hypertensives with Lacuna Infarction

目的 探讨转移生长因子β1（TGFβ1）在高血压合并腔隙性脑梗死中的作用。方法 46例经核磁共振明确诊断为高血压合并腔隙性脑梗死的病人,用双抗体夹心（ELISA）法测定血清TGFβ1浓度,并与无腔隙性脑梗死的高血压病人及正常人进行比较。结果 高血压合并腔隙性脑梗死的病人血清TGFβ1浓度为41.3±7.4ng/ml,显著高于正常人（26.4±6.3ng/ml）,但与无腔隙性脑梗死的高血压病人（40.9±7.3ng/ml）比较无显著性差异（P>0.05）。结论 TGFβ1在合并腔隙性脑梗死的高血压没有进一步升高,可能反映缺血性损伤与出血性损伤在发病机制或病理变化上的差异,但不能排除TGFβ1对脑缺血性损伤的不良作用。

Objective To explore into the potential function of transforming growth factor β1 in hypertensives with lacuna infarction. Methods The lacuna infarction in hypertensive patients was diagnosed definitely by MR. The level of transforming growth factors β1 in serum of hypertensives with or without lacuna infarction and normotensives was measured with ELISA. Results The level of serum in hypertensives with lacuna infarction was 41.3±7. 4ng/ml. The value was higher than that in normotensives (26. 4±6. 3ng/ ml). There was no significant difference between hypertensives with or without lacuna infarction. The viscosity of plasma and blood in hypertensives with lacuna infarction was higher than that in hypertensives without lacuna infarction. Conclusion The increased level of transforming growth factors β1 in serum may play a role in the development of hypertension. Its damage effect on the target organ brain can not be excluded.