手性丙三醇衍生物的合成(英文)

Synthesis of Chiral Glycerol Derivatives

以天然酒石酸为原料 ,设计并合成了一个未见文献报道的手性丙三醇衍生物即R 2 苯甲氧基 3 ( 2 四氢吡喃氧基 )丙醇 ,及用新方法制备了R 2 苯甲氧基 3 ( 4 甲氧基苯甲氧基 )丙醇。它们是合成溶血磷脂酸 (LPA) ,血小板活性因子 (PAF) 。

One new chiral derivative of propanetriol,(R)-2-benzyloxy-3-(2-tetrahydropyranyloxy) propanol was designed and synthesized;and (R)-2-benzyloxy-3-(4-methoxybenzyloxy) propanol was prepared with a new method using natural tartaric acid as starting material.They are chiral synthons for lysophosphatidic acid,platelet-activating factors,lipoteichoic acid,and other compounds containing asymmetric propanetriol backbone.