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神经元上的小电导钙激活钾通道的研究进展 被引量：1

Small conductance Calcium-activate potassium channel on neurons
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摘要 小电导的钙激活钾通道 (SK)具有K+ 选择性 ,Ca2 + 高敏性和电压不依赖等特性 ,广泛分布在神经元上。参与产生慢后超级化电位 ,通过放电频率适应影响神经元的放电功能。SK通道主要包括SK1,SK2 ,SK3 3种通道 ,通道活性受Ca2 + ,钙调蛋白 (CaM )以及一些神经递质的调节。SK通道的改变可能与学习记忆失调 。 Small conductance Ca 2+ activated potassium channels ( SK channels) are potassium selective , voltage independent, and Ca 2+ high sensitivity. SK channels are widely distributed in neurons. SK underlie the slow afterhyperpolarization , which regulate the fire of neurons by spike frequency adaptation. Three mammalian SK channels (SK 1, SK 2, SK 3) have been cloned . Ca 2+ , CaM and neurotransimitters involve in the gating of these channels. The changes of these channels may result in memory, neuromuscular disorder and schizophrenia.
作者 金宏伟 王晓良
机构地区 中国医学科学院.中国协和医科大学药物研究所
出处 《中国药理学通报》 CAS CSCD 北大核心 2002年第5期486-489,共4页 Chinese Pharmacological Bulletin
基金 国家重大基础项目研究计划资助课题(NoG19980 5 110 6) 国家杰出青年科学基金资助课题 (No 3 942 5 0 14 )
关键词 小电导钙激活钾通道 慢后超级化电位 钙调蛋白 神经元 神经递质调节 small conductance Ca 2+ activated potassium channels(SK channels) slow afterhyperpolarization CaM
分类号 R322.8 [医药卫生—人体解剖和组织胚胎学] R338 [医药卫生—人体生理学]
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参考文献12

  • 1Stocker M, Krause M, Pedarzani P. An apamin-sensitive Ca2+-activated K+ current in hippoCampal pyramidal neurons. Proc Natl ACad Sci USA,1999;96(8):4662～7
  • 2Wikstrom MA, El Manira A. Calcium influx through N- and P/Q-type channels activate apamin-sensitive calcium-dependent potassium channels generating the late afterhyperpolarization in lamprey spinal neurons. Eur J Neurosci,1998;10(4):1528～32
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中国药理学通报
2002年 第5期

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