摘要
目的 研究异亚丙基莽草酸 (ISA)对大脑中动脉栓塞模型 (MCAT)大鼠脑组织自由基代谢的影响。方法 采用三氯化铁致大脑中动脉栓塞模型 ,观察ISA对脑组织总超氧化物歧化酶 (T SOD)、Cu Zn SOD、谷胱甘肽过氧化物酶(GSH px)活力及丙二醛 (MDA)含量的影响。 结果 ISA2 0 0 ,10 0mg·kg-1可提高模型大鼠脑组织T SOD活力 ;ISA2 0 0 ,10 0 ,5 0mg·kg-1均可明显增加模型大鼠脑组织Cu Zn SOD和GSH px活力 ;ISA 2 0 0 ,10 0 ,5 0mg·kg-1对模型大鼠脑组织MDA升高有明显的抑制作用。
AIM To study effect of 3,4 oxo isopropylidene shikimic acid(ISA) on free radical metabolism in the brain issue of rats subjected to middle cerebral artery thrombosis.METHODS Adopt a middle cerebral artery thrombosis model to determine the activity of T SOD, Cu Zn SOD, MDA and GSH px of brain issue of rats by the way of colorimetry.RESULTS ISA 100 and 200 mg·kg -1 ig for 2 times in 24 hours raised the activity of T SOD;ISA 50, 100 and 200 mg·kg -1 ig,increased the activity of Cu Zn SOD and GSH px in rats brain issue ;ISA 50, 100 and 200 mg·kg -1 ig for 2 times in 24 hours,decreased the content of MDA in rats brain issue. CONCLUSIONS ISA protect brain issue from the ischemic damage by modifying the free radical metabolism.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2002年第5期569-571,共3页
Chinese Pharmacological Bulletin
基金
国家中医药管理局"十五"攻关项目No 2 0 0 1BA70 1A0 7 14
