摘要
测定常压下阿司匹林在乙醇中的溶解度及介稳区数据(283.05—322.98 K),实验中采用的方法是动态激光法。实验结果表明在乙醇中的溶解度随着温度的升高而增大,介稳区的宽度随着温度的升高而变窄,随着降温速率的增大而变宽;并通过固液相平衡简化热力学方程和Apelblat方程模型对其溶解度数据进行关联,结果表明2种模型可以很好地对数据进行拟合。通过范德霍夫热力学方程计算得出阿司匹林在乙醇中的溶解焓为28.683 k J/mol,其溶解熵为72.438 J/(mol·K)。
The solubility and metastable zone of Aspirin in ethanol( 283. 05-322. 98 K) were measured in the ambient pressure with dynamic laser method. The results show that the solubility of aspirin in the ethanol increases with temperature rise,and the width of the metastable zone narrows with temperature rise and widens with increasing of cooling rate. Two solubility models,the solid-liquid equilibrium simplified thermodynamic equation and Apelblat equation,were employed to regress these solubility data and the results show that the two equations are suitable for correlating the data. The Van't Hoff equation was used to calculate the dissolution enthalpy and dissolution entropy of solution in the ethanol system, the dissolution enthalpy was 28. 683 k J / mol and the dissolution entropy was 72. 438 J /( mol·K).
出处
《化学工程》
CAS
CSCD
北大核心
2015年第10期35-38,共4页
Chemical Engineering(China)
基金
国家"十二五"专项课题资助项目(2011ZX09401-023)
关键词
阿司匹林
激光法
介稳区
溶解度
溶解度模型
aspirin
laser method
metastable zone
solubility
solubility model
