性别间和家庭聚集的幽门螺杆菌感染的Meta分析

Meta-analysis on Helicobacter pylori infection between sex and in family assembles

目的 综合分析并探讨幽门螺杆菌感染情况。方法 运用Meta分析方法对幽门螺杆菌性别间和家庭聚集的研究进行综合定量分析。结果 性别间幽门螺杆菌感染率有细微差别 ( 95 %CI :0 .0 5 79～ 0 .0 963 ) ;父母均阳性子女幽门螺杆菌感染率较父母均阴性者为高 ( 95 %CI :0 .3 3 78～0 .5 0 42 )。结论 幽门螺杆菌感染率存在性别差异和家庭聚集现象 ,幽门螺杆菌流行病学研究涉及很多方面 ,但均缺乏足够调查和证据 。

Objective To understand and analyze the infection situation of Helicobacter pylori (H.pylori). Methods Extensively reviewing Chinese literature collecting the related with electronic documents in combination with manual retrieve and using Meta-analysis to do a quantitive analysis. Results Slight difference in the infection rate of H.pylori between men and women (95%CI: 0.057 9- 0.096 3) was noticed. The infection rate of H.pylori in children whose parent was positive with infection of this bacteria was higher than that of children whose parent was negative (95%CI: 0.337 8- 0.504 2). Conclusion The infection rate of H.pylori showed gender difference with nature of family aggregation. Epidemiological studies of H.pylori was comprehansive and involved many aspects. Further investigation needs to be focused on infection rate and other risk factors.