摘要
微波加热可以明显促进卤素交换氟化反应的速率,实验结果显示它比常规加热具有更高的选择性和产率。季铵盐、聚乙二醇和三氯化锑都可作为有效的催化剂,其中四甲基氯化铵和PEG-6000由于稳定而效果最好,在微波反应条件下以二甲亚砜为溶剂反应4h可分别得到产率75 1%和77 2%的邻硝基氟苯,反应时间大大缩短,产率明显提高。
Microwave could promote the halogen-exchange fluorination rate tremendously and gave higher selectivity and yield than traditional heating method. Quaternary ammonium salts, polyethylene glycol and antimony trichloride acted as effective catalysts in this reaction. Among these, tetramethylammonium chloride and PEG-6000 were the best owing to their high stability. Using these catalysts, o -fluoronitrobenzene could be obtained with yields of 75 1% and 77 2% respectively after reacting in DMSO for 4 h under microwave irradiation . The reaction time was shortened and the yield increased greatly.
出处
《石油化工》
CAS
CSCD
北大核心
2003年第1期37-40,共4页
Petrochemical Technology
关键词
微波促进
邻硝基氟苯
合成
卤素交换
季铵盐
聚乙二醇
三氯化锑
o-fluoronitrobenzene
halogen-exchange
microwave
quaternary ammonium salts
polyethylene glycol
antimony trichloride
