摘要
以dl-2-哌啶酸为原料通过拆分制得L-2-哌啶酸。用D-(-)-酒石酸与dl-2-哌啶酸成盐的化学法,结合选择吸附法和晶种结晶法制得纯度较高的单一异构体。制得L-2-哌啶酸总收率为70.8%,纯度为99.4%,可作为合成纯左旋体罗哌卡因的起始原料。化学成盐拆分法结合选择吸附法和晶种结晶法能制得高纯单一异构体。
L-pipecolinic acid was manufactured with dl-pipecolinic acid as primary materi al. The methods included chemical method of the incorporation of D---tartaric acsid and dl-pipecolinic acid selective adsorpt ion and seeded growth crystallization.The purity of the product was 99.4% and it was suitable for the synthesis of ropivacaine. The methods was practicable to gain single isomeride with a high purity.
出处
《安徽化工》
CAS
2002年第6期20-21,共2页
Anhui Chemical Industry
关键词
拆分法
制备
L-2-哌啶酸
罗哌卡因
晶种结晶
药物
L-pipecolinic, ropivacaine, enantio meric separation,seeded growth crystalliz ation
