肿瘤细胞端粒酶活性在放免治疗中的意义

The Function of Telomerase Activity in the Tumor Suppression Mechanism of Radioimmunotherapy

采用不同给药方式对实验动物进行放免治疗(RIT),观察其抑瘤效果,并检测各组实验动物治疗后原发和转移灶肿瘤细胞的端粒酶活性。结果显示,各治疗组抑瘤效果均优于对照组;多次小剂量效果更佳(P<0.05);实验小鼠原发肿瘤组织和肺转移瘤组织肿瘤细胞均具有较高的端粒酶活性;治疗后均引起端粒酶活性下降(P<0.05),且多次小剂量组比单次大剂量组下降明显(P<0.05)。

Mice bearing pulmonary adenocarcinoma models are treated with 188ReCL58. The effect judged through body weight loss, tumor burden and metastatic involvement of the organs are compared among the multiple low dose RIT, single large dose RIT and controls after successful implantation of tumor. When the treatment is initiated the 5th day after implantation, the tumor suppression effects of treatment groups are significantly better than controls, better results are achieved in 188ReCL58 multiple low dose RIT. Telomerase activity of tumor cells are detected before and after RIT, the activity is significantly brought down by RIT, and multiple low dose RIT is more efficient than single large dose RIT. The results show that multiple low dose RIT is more efficient for inhibition of telomerase activity.