1-取代苯基-1,4-二氢-6-甲基-4-哒嗪酮-3-酰肼衍生物的合成及生物活性

Hydrazine Derivatives of 1-Aryl-1,4-dihydro-3-carboxy-6-methyl-4-pyridazone. Synthesis and Biological Activity

以 1 取代苯基 3 羰基肼 1,4 二氢 6 甲基 4 哒嗪酮为原料 ,进行衍生化 ,合成了哒嗪酮的酰腙、酰氨基取代脲、N 乙氧基羰基羰基肼、N 氯乙酰基羰基肼等五类新型化合物 ,并研究其生物活性 .初步生物活性测试表明目标化合物对烟草花叶病毒 (TMV)、水稻纹枯病 (Pelliculariasasakii)和小麦锈病 (Pucciniareconditatritici)具有一定的抑制作用 .其结构经元素分析、红外光谱及1HNMR确证 .

Five series of new hydrazine derivatives of 1-aryl-1, 4-dihydro-3-carboxy-6-methyl-4-pyridazones have been synthesized and characterized by spectral and elemental analyses. Some of the compounds showed significant inhibition against TMV, Pellicularia sasakii and Puccinia recondita tritici.