(±)-16-羟基-6,7-脱氢铁锈醇甲醚及其类似物的合成

Synthesis of 16-Hydroxy-6,7-didehydraferruginyl Methyl Ether and Its Analogues with 16-Oxidant Group

采用 AC→ ABC的合成策略 ,以α-环柠檬醛为 A环起始原料 ,通过与 C环化合物 8缩合、选择性还原及分子内环合得到关键中间体 1 1 ,再经过官能团修饰和转换 ,合成了 1 6 -羟基 -6 ,7-脱氢铁锈醇甲醚及其 3个类似物 .

The synthetic strategy of AC→ABC was used, in which α-cyclocitral was used as A ring synthon. The key intermediate 11 was obtained after condensation of α-cyclocitral with triphenyl phosphonium chloride 8, sequently selective reduction by Pd/C and intramolecular cyclization. 16-Hydroxy-6,7-didehy-draferruginyl methyl ether and three analogues with 16-oxidant group were synthesized from this key intermediate via structure modification.