HBsAg无症状携带者血清HBV DNA与Pre S_2关系初探

Study of Serum HBV DNA and Pre S_2 from HBsAg Asymptomatic Carriers

应用Dig-HBV DNA探针点杂交检测96例HBsAg无症状携带者血清HBV DNA,同时检测其HBsAg、抗HBs、HBeAg、抗HBe、抗HBc及Pre S_2。结果表明,HBV DNA与HBeAg及Pre S_2有着极为密切的平行关系。Pre S_2与HBV DNA阳性强度基本符合,Pre S_2可作为HBV复制的敏感指标。HBVDNA与抗HBc无直接关系,说明抗HBc仅能作为HBV感染的一项指标。抗HBe阳性,患者传染性低,但不排除其具有传染性的可能。

Dot-hybridization with Dig-HBV DNA probe was used to detect serum HBV DNA from 96 HBsAg asymptomatic carriers and also detect their HBsAg, anti-HBs, HBeAg, anti-HBe, anti-HBc and Pre S_2. The results show HBV DNA, HBeAg and Pre S_2 had very close balance relationship. The positive inten- sity of Pre S_2 was in accord with that of HBV DNA. Therefore, Pre S_2 can be used as a sensitive index of HBV replication. There was no direct relationship between HBVDNA and anti-HBc. It indicates that anti-HBc can serve as an index of HBV infection. when anti-HBe was positive indicate the patients were less infection, but this can not rule out the possibility of HBV infection.