云南24个民族群体GSTT1、GSTM1纯合缺失基因型频率的分布

Frequencies distribution of GSTT1 and GSTM1 null genotypes in 24 Yunnan populations

目的 调查 GSTT1,GSTM1纯合缺失基因型频率在云南民族群体和地理上的分布。方法采用聚合酶链式反应的方法 ,对云南省 11个地区 2 4个民族群体进行 GSTT1,GSTM1基因型分析。结果GSTT1和 GSTM1纯合缺失基因型频率在民族间的分布分别为 0 .188～ 0 .6 33、0 .4 0 0～ 0 .74 5 ,地区间分布分别为 0 .2 86～ 0 .5 83、0 .4 33～ 0 .74 5 ;基因频率与民族差异在 GSTT1基因中存在统计学上的显著关系 ,而在 GSTM1中无显著关系。基因频率与地区差异在统计学上无显著关系。结论 GSTT1,GSTM1纯合缺失基因型频率在云南各民族群体中存在差异 ,但在地区分布上比较均一。

Objective: To investigate the frequencies distribution of GSTT1 and GSTM1 null genotypes in 24 Yunnan populations. Methods: GSTT1 and GSTM1 genotypes were analyzed by PCR procedure. Results: The range of frequencies for GSTT1 and GSTM1 null genotypes in the populations were 0. 188-0. 633 and 0. 400-0. 745, respectively, and in the districts were 0. 286-0. 583, 0. 433-0. 745 respectively. There was significant relationship between GSTT1 frequencies and populations. Conclusion: The frequencies of GSTT1 and GSTM1 null genotypes in 24 Yunnan populations were different, but they were almost the same in different districts of Yunnan.