阿尔茨海默病患者中胰岛素与β样淀粉蛋白的关系

The association of insulin and plasma concentration of β-amyloid in Alzheimer's disease.

目的 研究阿尔茨海默病(AD)患者外周血胰岛素与β样淀粉蛋白水平的关系。方法 患者为上海市1997-1998年的痴呆流行病学调查中的确诊病例,对照组为病例组的同社区居民,测定外周血的胰岛素与β样淀粉蛋白水平。结果 AD组的胰岛素水平(25.56±19.12μIU/mL)高于正常对照(15.88±11.05μIU/mL),两组相比有显著性差异(H=10.5,P<0.05),AD组β样淀粉蛋白水平(21.24±9.4 pg/mL)也高于对照(16.03±7.25 pg/mL)两组相比有显著性差异(H=13.1,P<0.05),随年龄的增长,90岁以前β样淀粉蛋白的量无明显变化,AD组与对照组的胰岛素量都呈下降趋势。β样淀粉蛋白与胰岛素(偏回归系数0.017,P>0.05)和年龄(偏回归系数0.082,P>0.05)差异没有显著性。结论 AD患者胰岛素水平与β样淀粉蛋白水平有关。

Objective To study the association of insulin and the plasma concentration of β-amyloid in Alzheimer's disease (AD). Methods All cases were participants who were diagnosed in the investigation in Shanghai between 1997 and 1998. The concentration of plasma insulin and β-amyloid were tested by radiological immunology analysis. Results Patients with AD had higher insulin level (25.56±19.12 μIU/mL) than normal control group (15.88 ± 11.05 μIU/mL), There was significantly different between the two group ( H = 10.5,P<0.05). Compared with control group, patients with AD had higher β-amyloid level (21.24±9.4 pg/mL) than normal control group (16.03±7.25 pg/mL)。 There was significantly different between the two groups (H=13.1, P<0.05). There's no statistical significance between the β-amyloid level and insulin ( r = 0.017, P>0.05)or age ( r =0.082, P > 0.05). Conclusions There was association between insulin and β-amyloid concentration in Alzheimer's disease.