碱性成纤维细胞生长因子在烟雾病发生机制中的作用

The role of basic fibroblast growth factors in the pathogenesis of moyamoya disease

目的 研究脑脊液中碱性成纤维细胞生长因子(bFGF)在烟雾病发病机制中的作用。方法 利用酶联免疫吸附试验(ELISA)测量烟雾病病人组、缺血对照组以及非缺血对照组病人脑脊液中的bFGF浓度,并进行统计学分析。烟雾病病人15例,13例行双侧颈内动脉外膜剥脱术加额颞钻孔术治疗。结果 15例烟雾病病人脑脊液中,12例检出bFGF,平均含量为(30.1±26.1)ng/L,缺血对照组中仅1例检出bFGF,浓度为0.24 ng/L;非缺血对照组未检出bFGF。烟雾病病人脑脊液中bFGF含量明显高于对照组(P<0.01)。结论 碱性成纤维细胞生长因子(bFGF)在烟雾病发生、发展过程中有重要作用。脑脊液中高水平的bFGF可能参与了颈内动脉的狭窄或闭塞。同时又促进血管新生,异常血管网的形成。

Objective To investigate the role of basic fibroblast growth factor in the pathogenesis of moyamoya disease. Methods Using enzyme-linked immunoadsorbent assay method, the concentrations of basic fibroblast growth factor in the cere-brospinal fluid of the following patients were measured: Moyamoya disease group (15 cases), ischemic control group(10 case) , and non-ischemic control group (8 case) . 13 of the 15 patients with Moyamoya disease were treated by stripping the tunica adventi-tia of bilateral internal carotid artery and driling on the frontotemporal skull. Results The average concentration of bFGF in 12 of the 15 patients with moyamoya disease was 30±26.1 ng/L. bFGF was found in only one patient in the ischemic control group with concentration of 0.24 ng/L. bFGF was not defectable in the non-ischemic disease group. The bFGF's average concentration in patients with moyamoya disease was significantly higher than that in the control patients ( P < 0. 01) . Conclusions bFGF has a great role in the occurrence and development of moyamoya disease. High concentration of bFGF may possibly lead to the constriction and obstruction of internal carotid artery and formation of new blood vessels.