脑梗死患者脑脊液和血清中脂蛋白(a)的含量变化观察

The observation of content changes of lipoprotein (a) in serum and cerebrospinal fluid of patients with cerebral infarction.

目的 :观察脑梗死患者脑脊液和血清中脂蛋白 (a)的含量变化。方法 :选择 40例脑梗死患者和 2 0例对照者 ,用酶联免疫法测定脂蛋白 (a)在脑脊液及血清中的含量。结果 :脑梗死患者与对照者脑脊液中脂蛋白 (a)含量分别为 (2 4 0± 2 7) μg L及 (2 1 2± 2 2 ) μg L,血清中脂蛋白 (a)含量分别为 (0 30 2± 0 0 35) μg L及 (0 2 67± 0 0 33) μg L,脑梗死组脑脊液及血清中脂蛋白 (a)含量明显高于对照组 (P <0 0 1 )。两组脑脊液与血清中脂蛋白 (a)水平均无相关关系 (P >0 0 5)。结论 :脑梗死患者脑脊液及血清中脂蛋白 (a)水平明显高于对照组。提示脂蛋白 (a)

Objective:To observe the content changes of Lipoprotein(a)in serum and cerebrospinal fluid(CSF)of patients with cerebral infarction.Methods:Forty patients with cerebral infarction and twenty cases of control were selected,and the contents of Lipoprotein(a)in serun and cerebrospinal fluid were detected by enzyme-linked immunosorbent assay(ELISA).Results:The contents of Lp(a)in CSF of patients with cerebral infarction and the cases of control group were(240±27) μg/L and (212±22) μg/L respectively,the contents of Lp(a)in serum of patients with cerebral infarction and the cases of control group were(0 302±0 035) g/L and (0 267±0 033) g/L respectively,the contents of Lp(a) in serum and CSF of the patients with cerebral infarction were significantly higher than that of control group(P<0 01),the level of Lp(a) in serum and CSF in two groups had not correlation (P>0 05).Conclusions:The level of Lp(a) in serum and CSF of the patients with cerebral infarction were significantly higher than that of control group,it indicated that the Lp(a) was primary index which could reflect Lipodystrophy in the patients with cerebral infarction.