1Li YM, Xu M, Lai MT, et al.Photoactivated g-secretase inhibitors directed to the active site covalently label presenilinl. Nature, 2000, 405(6787): 689～94.
2Esler WP, Kimberly WT, Ostaszewski BL, et al.Transition-state analogue inhibitors of g-secretase binds directly to presenilin-1. Nature Cell Biol, 2000, 2(7):428～34.
3Delacourte A, David JP, Sergeant N, et al. The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer ' s disease. Neurology, 1999, 52(6) :1158～65.
4Marie TH. Alzheimer' s disease: Plaque removers and shakes. Nature, 2000,406(6795): 465.
6Du YS, Zhu H, Fu J, et al.Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer' s disease. Proc Natl Acad Sci USA, 1997, 94: 5296～301.
7Iijima K, Ando K, Takeda S, et al. Neuron-specific phosphorylation of Alzheimer' s beta-amyloid precursor protein by cyclin-dependend kinase 5.J Neurochem, 2000, 75(3): 1085～91.
8Neve RL. A beta may be a planet,but APP is central. Neurobiol Aging, 2001,22(1): 151-4.
9Ohgoh M, Shimizu H, Ogura H, et al. Astroglial trophic support and neuronal cell death: influence of cellular energy level on type of cell death induced by mitochondrial toxin in cultured by mitochondrial toxin in cultured rat cortical neurons. J Neurochem, 2000, 75: 925～ 33.
10Bullido MJ, Aldudo J, Frank A, et al.A polymorphism in the tau gene associated with risk for Alzheimer' s disease. Neurosci Lett, 2000, 278: 49～ 52.
二级参考文献6
1Liu R Y，J Clin Endocrinol Metab，1999年，84卷，323页
2徐庆中，老年性痴呆:从分子生物学到临床诊治（第2版），1998年，79页
3Li W P，J Mol Neurosci，1997年，8卷，75页
4Edwards A D，Biochem Biolphys Res Commun，1995年，217期，1193页
