3Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain , breast , and prostate cancer. Science, 1997,275 ( 5308 ) : 1943 - 1947.
4LijimaM, HuangYE, Ln HR et al. Novelmechanism of PIEN regulation by its phosphatidylinositol 4,5 - bisphosphate binding motif is critical for chemo - taxis. J Biol Chem,2004,279(16) :16606 - 16613.
5Lee JO,Yang H, Georgescu MM, et al. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell, 1999,99 (3) :323 -334.
6Raftopoulou M, Etienne - Mannevile S, Self A, et al. Regulation 6f cell migration by the C2 domain of the tutnor suppressor PIEN. Science, 2004,303(5661 ) :1179 - 1181.
7Valiente M, Andres. Pons A, Gomar B, et al. Binding of PTEN to specific PDZ domains contributes to PIEN protein stability and phosphorylation by micmtubule - associated serine/threonine kinases. J BioZ Chem, 2005,280 (32) :28936 - 28943.
8Miller SJ, Lou DY, Seldin DC, et al. Direct identification of PTEN phosphorylation sites. FEBS Letters ,2002,528 : 145 - 153.
9Maxwell GL, Bisinger JI, Gumbs C, et al. Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias. Cancer Res. 1998 , 15 ; 58(12) :2500 -2503.
10Weng L, Brown J, Eng C. PTEN induced apoptosis and cell cycle arrest through phosphoinsi to 123 kinase pak dependent and independent pathways. Hum Mol Genet, 2001,10 ( 3 ) : 237 - 242.
