阿霉素磁性蛋白微球靶向治疗胃癌的病理改变观察

Pathological Changes of Targeting Treatment with Adriamycin Magnetic Albumin Microspheres in Human Gastric Carcinoma

目的 探讨术前应用阿霉素磁性蛋白微球联合外磁场靶向疗法后胃癌组织的病理组织学改变。方法 对3 0例术前应用靶向疗法的胃癌手术标本和 3 0例对照标本进行组织切片 ,观察癌组织的病理变化 ,根据标准判断病理改变分级。结果 靶向治疗组的细胞变性坏死分级高于对照组。靶向组中组织学类型不同的癌细胞改变分级也不同 ,中 -低分化腺癌改变分级较高 ,中重度改变达 5 7.9% ,而粘液细胞型腺癌均为 0级改变。结论 靶向疗法可加重癌组织的变性坏死 ,阿霉素磁性蛋白微球联合外磁场作为胃癌的术前辅助性化疗具有一定的应用价值 。

Objective To study the pathological changes in gastric carcinoma tissues as a result of preo-perative targeting treatment with adriamycin magnetic albumin microspheres (ADM-MAM) combined with the external static magnetic fields. Methods Thirty cases of gastric carcinoma after targeting treatment and 30 control cases were chosen. The stomach resection specimens were observed by pathological tissue sections. Results The grade of degeneration and necrosis change was higher in targeting treatment group than in control group. In targeting treatment group, different grades of degeneration and necrosis change happened in different tissue types. The grade of the pathological changes was rather high in middle-lower differentiated adenocarcinoma. The percentage of middle-serious change reached 57.9 %. However, no change was found in mucous cell adenocarcinoma. Conclusion The targeting treatment can induce degeneration and necrosis of carcinoma tissues except mucous cell adenocarcinoma. The administration of ADM-MAM combined with the external static magnetic fields is of some clinical value as a preoperative adjuvant chemotherapy for human gastric carcinoma, but it is inadvisable to use in the mucous cell carcinoma.