祛白酊中补骨脂素和异补骨脂素透皮效果的实验研究

Transdermal Effect of Osteopractic and Iso-osteopractic Lipids in Antileukoderma Tincture

目的 :考察祛白酊中君药补骨脂有效成分补骨脂素和异补骨脂素的透皮效果。方法 :采用简单小室法 ,以离体大鼠皮肤为透皮屏障 ,用双波长薄层扫描法测定体外接收液中补骨脂素和异补骨脂素的含量 ,进而计算累积透皮量和透皮率 ,并与未加月桂氮酮和二甲基亚砜的祛白酊透皮效果进行了实验性比较。结果 :补骨脂素的 8h累积透皮量与透皮率分别为 (92 6 5±2 91) μg·ml-1和 (84 6 6± 2 6 6 ) % ,异补骨脂素的 8h累积透皮量与透皮率分别为 (86 37± 2 6 7) μg·ml 1和 (82 2 9± 2 5 4 ) % ,与未加月桂氮酮和二甲基亚砜制剂的透皮效果比较 ,有显著性差异 (P <0 0 1)。结论

Objective:To observe the transdermal effect of ostopractic lipid and isoosteopractic lipid in antileukoderma tincture. Method:the simple cell method is used, the separated skin from a rat is served as a transdermal the content of osteopractic and iso osteopractic lipids in externally accepting liquid is determined by the double wave length and thin layer scanning, and the accumulative total amount and the fransdermal rate is calculated in addition, campare d with the transdermal effect of antileukoderma tincture without transdermal promoting agents. Results The 8h accumulating amount of osteopractic lipid and the transdermal rate are (92 65±2 91) μg·ml -1 and (84 66±2 66)%, respectively The 8h accumulating amount iso osteopractic lipid and the fransdermal rate are (86 37±2 67)μg·ml -1 and(82 29±2 54)%, raspectively. It showsed that coampared the significant difference with the transdermal without transdermal promoting agent ( P <0 01). Conclusions:The antileukoderma tincture have a better transdermal effect.