摘要
目的 :探讨手术创伤对肠道菌群的影响。方法 :2 0例大肠癌患者 ,均接受手术治疗 ;用选择性培养基平板对术前及术后第 1次粪便进行细菌培养。结果 :与手术前相比 ,手术后肠杆菌和肠球菌分别增加了 5倍 ,P <0 0 1和 3倍P <0 0 5 ;而双歧杆菌和真杆菌则分别下降了 75 0 % ,P <0 0 1和 6 7 6 % ,P <0 0 5 ;双歧杆菌 /大肠杆菌的比值 (B/E)倒置更为明显 ,P <0 0 0 1;肠道菌群失调由 35 %增加到 6 5 % ,P <0 0 5。结论 :手术创伤可引起肠道菌群失调。
Objective:To investgate the impact of operation trauma on gut flora in patients with colorectal cancer.Methods:Twenty randomly chosen patients with colorectal cancer were enrolled in this study. The bacteria were cultured with faeces samples collected prior to the operation and the first one after operation by using the selecting culture medium.Results:As compared with before operation, E. coli. and coccus in the gut after operation respectively increased 5-fold(8.63+0.48 vs 7.92+1.02,P<0.01)and 3-fold(7.40+1.40 vs 6.92+1.15,P<0.05),and bacteria bifid and fungus respectively decreased by 75.0%(7.03+0.48 vs 7.66+0.53,P<0.01)and 67.6%(6.48+0.83 vs 7.33+0.65,P<0.05).All the changes resulted in an incnease of the gut flora maladjustment from 35% to 65%(P<0.05). Conclusion:The operation trauma may result in gut flora maladjustment.
出处
《西南国防医药》
CAS
2003年第1期23-25,共3页
Medical Journal of National Defending Forces in Southwest China
关键词
大肠肿瘤
应激障碍
创伤后
肠道菌群
colorectal neoplasms
stress disorders
post-trauma
gut flora
