38例肺源性脑转移瘤临床病理分析

Clinical and Pathological Study of Metastatic Brain Tumors of the 38 Cases of Lung Carcinoma

目的 肺源性脑转移瘤临床病理特征。方法 研究38例肺源性脑转移瘤的临床和病理特点,男性27例,女性11例;年龄在30-74岁之间。其中5例转移性癌作免疫组织化学染色和电镜观察。结果 20例为腺癌,12/20为乳头状腺癌;5例为腺鳞癌,7例为鳞形细胞癌,4例为燕麦细胞癌,2例为不典型类癌;5例乳头状腺癌作免疫组织化学染色示CK(5/5)和CEA(4/5)为阳性;电镜显示转移性乳头状腺癌具有肺泡Ⅱ型上皮细胞分化潜能。结论 肺癌中腺癌更易发生脑转移,免疫组织化学在鉴别诊断中有一定的辅助作用,转移性乳头状腺癌具有异质性。

Objective To explore the clinieopathological characteristics of metastatic brain tumors (MBT) of the lung. Methods There were 38 cases . including 27 males and 11 females. The ages were 30 - 74 years old. In 5 cases of metastatic papillary adenocarcinoma of the brain were studied with immunohistochemieal stains and electron microscopy. Results 20 cases were adenocarcinoma 12/20 were papillary adenocarcinoma. 7 cases were squamous cell carcinoma.4 cases were oat cell carcinoma.2 cases were atypical carainoid.CK(5/5) and CEA(4/5) of papillary adenocarcinoma were pasitive in the immunohistochemieal. Metastatic papillary adenocarcinoma of the brain appeared with differentiated alveolar type Ⅱ epithelical cells. Conclusions Adenoearcinoma of lung carcinoma were easily had metastatic brain. Immunohistochemical method played an assistat rale in the identifying diagnosis and metastatic papillary adenocarcinoma of the brain had different heterogeneity.