C-erbB-2在乳腺癌中表达及与淋巴结转移的关系

The Expression of C - erbB -2 in Breast Cancer and Its Relationship to Lymph Node Metastasis

目的 探讨C-erbB-2在乳腺癌中的表达及与淋巴结转移的关系。方法 用免疫组织化学ABC法检测48例乳腺癌和10例乳腺良性疾病组织中C-erbB-2的表达。结果 1O例乳腺良性疾病有1例表达阳性(10.00％),而48例乳腺癌中有32例表达阳性(66.67％)。C-erbB-2的表达与淋巴结转移与否无明显相关性,而与肿瘤病理组织类型显著相关。结论 C-erbB-2过表达在乳腺癌发生发展中起一定作用,并可作为判断乳腺癌生物行为的一个有用指标。

Objective To detect the expression of C - erbB - 2 in breast cnacer and its relationship to lymph node metastasis. Methods The expression of C - erbB - 2 in 48 breast cancers and 10 breast benign neoplasms was studied with immunohistochemical ABC method. Results C - erbB - 2 was benign neoplasm specimens (Positive in 1 of 10) ,and it was positive in 32 of 48 breast cancers.The expression of C - erbB - 2 did not correlate with lymph node metastasis, but correlated significantly with Histopathology. Conclusion C - erbB - 2 may play an important role in the process of carcinogenesis in the breast, and be used as a useful marker for the assessment of biological behavior of breast cancer.