帕金森病大鼠行为学与黑质形态学变化的相关性研究

Experimental study of substantial nigral morphology and model of Parkinson disease rats

目的 观察帕金森病 (PD)大鼠行为学及其形态学特点。方法 通过 PD大鼠模型 ,采用行为学观察、TUNEL法、HE染色、Nissl染色、电镜方法 ,观察模型成功后 1 d、7d、1 4 d PD大鼠行为、形态学变化。结果 PD大鼠旋转圈数无明显变化 ,凋亡细胞、尼氏细胞逐渐减少 ,超微结构损伤逐渐加重。结论 PD大鼠旋转行为变化是有其病理学基础的。

Objective To observe the characteristics of praxiology and morphology of Parkinson disease(PD) rats.Methods At 1d,7d,14d after PD rats model were succeeded ,we used rotational behaviour, TUNEL,electronicmicroscopic,Nissl body staining methods to observe the characteristics of praxiology and morphology of Parkinson disease(PD) rats.Results In the group of PD rats, the rotational behaviour is not different . Apoptosic nigral cells, Nissl body decrease gradually. Electronicmicroscopic structure is severe by degrees.Conclusions Substantial nigral pathology of PD rats makes the foundation of the rotational behaviour.