胎盘因子对免疫功能及辐射所致造血功能损伤的影响

Effect of placenta factor on immune function and radiation-induced hematopoietic injury

目的进一步探讨胎盘因子(PF)的生物活性。方法 以免疫学和血液学常规方法观察PF对机体免疫功能和辐射所致造血功能损伤的影响。结果PF可提高小鼠腹腔巨噬细胞吞噬率(由对照组的16.15％提高到31.90％以上)、恢复T淋巴细胞的E-玫瑰花结形成能力(由对照组的32.70％提高到36.80％以上),并促进其转化,而且也可增加受照小鼠的脾集落形成单位(CFU-S)数(由对照组平均0.40个增加到1.91个)。结论PF具有细胞免疫调节作用,同时对受照机体的脾集落形成细胞也有一定的保护作用。

Objective To study the biological activity of placenta factor(PF) . Methods The influence of PF on immune function and radiation-induced hematopoietic injury was observed by using common methods in immunology and hematology. Results PF might increase the phagocytosis percentage of abdominal macrophage in mice(from 16.15% for controls to > 31.90% for PF) and recover the capacity of T lymphocytes to form E-rosette(from 32.70% for controls to > 36.80% for PF) as well as its transformation in human. In addition, PF might increase the number of CFU-S in irradiated mice(from 0.40 in average for controls to > 1.91 for PF). Conclusion PF might act as an immune modulator and have a certain protective effect on colony-forming cells in spleen for irradiated organism.